Research Articles
Crafting Molecular Handshakes: The Asymmetric Nitro-Mannich Reaction
Discover the breakthrough enantioselective reductive nitro-Mannich reaction using thiourea catalysis for precise molecular synthesis.
Exploring Microbial Natural Products at the Frontiers of Chemistry and Biology
Discover how microbial natural products are revolutionizing medicine through genomic mining and innovative discovery approaches like the iChip technology.
Nature's Blueprint for Pain Relief: The Botanical Hunt for Non-Opioid Drugs
Explore how scientists are decoding plant-based compounds to develop safer, non-opioid pain medications through medicinal chemistry and drug design.
The Tiny Ring with Mighty Power: A New Key to the Aziridine Puzzle
Discover the groundbreaking direct stereospecific synthesis of unprotected NH/NMe aziridines from olefins - a revolutionary approach in synthetic chemistry.
The Invisible Shield That Fails: How Worn-Out Surfaces Harbor Hidden Threats
Discover how aged PVC surfaces compromise disinfectant efficacy and create hidden bacterial reservoirs in healthcare and public spaces.
A Molecular Trojan Horse: Engineering a Smarter Cancer Fighter
Discover how scientists created a paclitaxel-coumarin conjugate that acts as a molecular Trojan horse to target cancer cells more precisely while reducing side effects.
The Hidden War: How Plants Wage Chemical Warfare to Survive
Discover the secret world of secondary metabolites—the molecules that give us coffee, cure diseases, and color our world.
Molecular Tattoo Artists: Teaching a Natural Enzyme to Decorate Our Medicines
Discover how algorithm-aided engineering transformed the enzyme WelO5* into a precision tool for drug discovery through late-stage functionalization.
The Invisible Language of Flowers: Capturing Nature's Most Elusive Perfume
Explore how scientists capture, analyze, and recreate the complex scents of flowers through advanced techniques like headspace sampling and GC-MS analysis.
The Fluorine Switch: How Chemists Tamed a Capricious Molecule
Discover how chemists transformed difluoromethyl sulfoximines from electrophilic to nucleophilic compounds, enabling stereoselective synthesis of valuable fluorinated molecules.