Research Articles
BioReCS: Mapping the Biologically Relevant Chemical Space of Natural Products for Accelerated Drug Discovery
This article explores the concept of the Biologically Relevant Chemical Space (BioReCS) for natural products (NPs), a focused subset of chemical space with inherent bioactivity.
Overcoming the Cell Barrier: Biotin Tagging Strategies for Enhanced Compound Permeability and Delivery
This article provides a comprehensive guide for researchers and drug development professionals on leveraging biotinylation to tackle persistent cell permeability challenges.
From Farm to Pharma: Taming Batch-to-Batch Variability in Natural Products for Robust Research and Drug Development
This article provides a comprehensive guide for researchers, scientists, and drug development professionals on addressing the critical challenge of batch-to-batch variability in natural products.
Reviving Lost Potential: Strategies to Recapitulate Bioactivity in Isolated Natural Compounds
This article addresses the critical challenge of bioactivity loss observed during the isolation of compounds from natural sources, biological extracts, or complex mixtures.
Unlocking Nature's Pharmacy: Activity-Based Protein Profiling for Natural Product Drug Discovery
This article provides a comprehensive guide to Activity-Based Protein Profiling (ABPP) as a transformative tool in natural product research.
Unlocking Nature's Pharmacy: Modern Strategies to Activate Silent Biosynthetic Gene Clusters for Novel Drug Discovery
This comprehensive review details the current state-of-the-art methods for activating silent or cryptic biosynthetic gene clusters (BGCs) in microorganisms, a critical frontier in natural product discovery.
Unlocking Nature's Pharmacy: A Comprehensive Guide to Accessing and Utilizing Natural Product Structures from ZINC
This guide provides researchers, scientists, and drug development professionals with a comprehensive framework for leveraging the ZINC database to access natural product (NP) structures for drug discovery.
Unlocking Nature's Pharmacy: X-ray Crystallography Fragment Screening for Natural Product Drug Discovery
This article provides a comprehensive guide to X-ray crystallography fragment screening with natural products, a cutting-edge approach in modern drug discovery.
WHALES Descriptors for Molecular Similarity: A Complete Guide for Chemoinformatics and Drug Discovery
This comprehensive article explores WHALES (Weighted Holistic Atom Localization and Entity Shape) descriptors, a powerful 3D molecular representation method for chemoinformatics.
Ultimate Guide to UPLC-ESI-QTOFMS Metabolomics Protocols: From Sample Prep to Data Validation
This comprehensive guide provides an in-depth protocol for UPLC-ESI-QTOFMS-based metabolomics, tailored for researchers and drug development scientists.