Research Articles
From Genes to Medicines: Unraveling the Biosynthesis and Biogenesis of Secondary Metabolites
This article provides a comprehensive exploration of the biosynthesis and biogenesis of secondary metabolites, crucial compounds with vast pharmaceutical and industrial applications.
Natural Product Drug Discovery in 2025: A Comprehensive Guide to Principles, AI Integration, and Future Opportunities
This article provides a comprehensive overview of the modern principles of natural product (NP) drug discovery, tailored for researchers, scientists, and drug development professionals.
Natural Products at the Crossroads of Chemical Biology and Systematics: A New Paradigm for Drug Discovery
This review synthesizes contemporary advances and methodologies at the intersection of natural product research, chemical biology, and biological systematics.
Navigating the Chemical Universe of Natural Products: From Structural Diversity to Drug Discovery Applications
This comprehensive review explores the vast chemical space and structural diversity of natural products (NPs) and their critical importance in modern drug discovery.
Natural Products in Modern Drug Discovery: From Biological Sources to Clinical Impacts
This comprehensive review explores the evolving landscape of natural products in pharmaceutical research and development.
Emerging Trends in Natural Products Chemistry: From Sustainable Discovery to Clinical Translation
This article explores the dynamic landscape of natural products chemistry in 2025, a field being reshaped by the convergence of sustainability demands, artificial intelligence, and advanced analytical technologies.
The Evolving Landscape of Natural Product Databases: A 2025 Review of Trends, Applications, and Challenges in Drug Discovery
This article provides a comprehensive analysis of the structural evolution and temporal trends in natural product (NP) databases from 2000 to the present. Tailored for researchers, scientists, and drug development professionals, it explores the foundational growth of over 120 NP resources, detailing the shift from commercial monopolies to open-access initiatives like COCONUT, which now aggregates over 400,000 non-redundant compounds. The review further examines the methodological applications of these databases in virtual screening, knowledge graph construction, and molecular generation. It addresses critical troubleshooting aspects related to data quality, stereochemistry, and accessibility, and offers a comparative validation of major commercial and public databases. By synthesizing two decades of progress, this article serves as an essential guide for leveraging NP databases to accelerate modern, computation-enabled drug discovery.
Comparative Assessment of Natural Product Scaffold Diversity: Unveiling New Avenues for Drug Discovery
This article provides a comprehensive comparative assessment of natural product scaffold diversity, exploring its critical role in modern drug discovery. It establishes the foundational principles of scaffold analysis, detailing key chemoinformatic methodologies used to quantify and compare structural diversity across compound libraries from various geographical and biological sources. The content addresses common challenges in scaffold analysis and library design, offering strategies for optimizing diversity. Through validation against approved drugs and synthetic libraries, it highlights the unique value of natural product scaffolds in accessing novel bioactive chemotypes. Aimed at researchers and drug development professionals, this review synthesizes key findings to guide the strategic utilization of natural product diversity for identifying new therapeutic leads.
From Orchard to Lab: How Apple Waste is Being Turned into Health Goldmines
Discover how green chemistry is transforming wild apple waste into valuable bioactive compounds using sustainable extraction methods.
Nature's Silver Bullets: The Eco-Friendly Revolution in Antimicrobial Technology
Discover how plant-based synthesis of silver nanoparticles offers sustainable antimicrobial solutions with significant effectiveness against pathogens.