Research Articles
Unlocking Nature's Chemical Library: Advanced UHPLC-HRMS² Strategies for Novel Natural Product Discovery
This article provides a comprehensive guide for researchers and drug discovery professionals on leveraging Ultra-High Performance Liquid Chromatography coupled with High-Resolution Tandem Mass Spectrometry (UHPLC-HRMS²) for the annotation of novel...
Comparative Analysis of Structural Features in Biologically Active Datasets: From Molecular Networks to Drug Discovery
This article provides a comprehensive comparative analysis of structural features in biologically active datasets for researchers, scientists, and drug development professionals.
Scaffold Hopping: Unlocking Novel Drug Leads by Bridging Natural Products and Approved Medicines
This article provides a comprehensive guide for researchers on scaffold overlap analysis, a pivotal strategy for discovering novel chemical entities by identifying shared or transformable molecular frameworks between natural products...
Benchmarking Natural Product Scaffold Diversity: A Comparative Analysis with Synthetic Drug Libraries for Enhanced Drug Discovery
This article provides a comprehensive analysis of benchmarking natural product scaffold diversity against synthetic drug collections, tailored for researchers and drug development professionals.
Murcko Frameworks Analysis: A Comparative Guide for Drug Discovery Datasets
This article provides a comprehensive analysis of the Murcko framework methodology for comparing the structural diversity and scaffold composition across different compound datasets, a critical task in virtual screening and...
Navigating Chemical Space: The Evolving Synergy Between Natural Product Diversity and Purchasable Compound Libraries
This article provides a comprehensive comparative analysis of natural product scaffolds and purchasable compound libraries, two foundational pillars in modern drug discovery.
Intelligent Prioritization: Transformative Strategies for Screening Natural Product Extracts in Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on modern, efficient methods for prioritizing natural product extracts for biological screening.
Rational Selection of Natural Product Scaffolds with Favorable ADME: A Modern Guide for Efficient Drug Discovery
This article provides a comprehensive roadmap for researchers and drug development professionals on the rational selection of natural product (NP) scaffolds with optimized absorption, distribution, metabolism, and excretion (ADME) properties.
Navigating Complexity: Modern Strategies for Deconvoluting Bioactive Natural Products from Complex Extract Libraries
This article provides a comprehensive guide for researchers and drug development professionals on the contemporary challenges and solutions in handling complex natural product extract libraries.
Optimizing High-Throughput Screening Hit Rates with Natural Products: AI, Library Design, and Integrated Strategies
Targeted at researchers and drug development professionals, this article provides a comprehensive overview of strategies to enhance hit rates in high-throughput screening (HTS) of natural products.