Research Articles
Unlocking Nature's Chemical Library: Advanced UHPLC-HRMS² Strategies for Novel Natural Product Discovery
This article provides a comprehensive guide for researchers and drug discovery professionals on leveraging Ultra-High Performance Liquid Chromatography coupled with High-Resolution Tandem Mass Spectrometry (UHPLC-HRMS²) for the annotation of novel...
PRISM 4 vs antiSMASH: A 2024 Comparative Analysis of Natural Product Prediction Accuracy for Drug Discovery
This article provides a comprehensive comparison of PRISM 4 and antiSMASH, the two leading genome mining platforms for predicting biosynthetic gene clusters (BGCs) of natural products.
PRISM 4: Next-Generation AI for Decoding Genomic Chemical Structures and Accelerating Drug Discovery
This article provides a comprehensive analysis of PRISM 4, a cutting-edge platform for genomic chemical structure prediction.
Beyond Synthesis: Optimizing NP-Likeness Scores for Drug Discovery in AI-Generated Compound Libraries
This article provides a comprehensive guide for researchers and drug development professionals on the critical role of Natural Product-likeness (NP-likeness) scoring in evaluating AI-generated compound libraries.
Decoding Nature's Pharmacy: A Comprehensive Guide to NMR Spectroscopy for Natural Product Characterization and Drug Discovery
This article provides a detailed, modern overview of Nuclear Magnetic Resonance (NMR) spectroscopy's pivotal role in characterizing natural products.
MTT Assay Protocol for Natural Products: A Complete Guide to Cytotoxicity Evaluation in Drug Discovery
This comprehensive guide details the MTT assay's application for evaluating natural product cytotoxicity, a cornerstone in drug discovery.
Decoding the Unknown: A Complete Guide to MS2 Spectral Annotation for Novel Compound Discovery
This comprehensive guide explores the critical challenge of annotating MS2 spectra for novel compounds where no reference standards exist.
Terpene Biosynthesis: A Comprehensive Guide to the MEP and MVA Pathways for Drug Discovery
This article provides a detailed examination of the two fundamental pathways for terpene biosynthesis—the Mevalonate (MVA) and Methylerythritol Phosphate (MEP) pathways—targeting researchers and drug development professionals.
The LEMONS Algorithm: Revolutionizing Natural Product Discovery Through Systematic Enumeration
This article provides a comprehensive guide to the LEMONS algorithm for enumerating hypothetical natural product (HNP) scaffolds, a cornerstone methodology in modern computational drug discovery.
Mastering LC-MS/MS Dereplication: A Comprehensive Guide for Natural Product Discovery and Drug Development
This article provides a detailed roadmap for researchers and drug development professionals to leverage Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the efficient dereplication of complex natural product mixtures.