Research Articles
Unlocking Complex Mixtures: How Micro-Fractionation Precisely Pinpoints Active Compounds to Accelerate Drug Discovery
This article provides a comprehensive guide to micro-fractionation, a pivotal technique for deconvoluting complex biological mixtures to identify the specific chromatographic peaks responsible for bioactivity.
Synergistic Integration of HR-MS and NMR for Comprehensive Metabolite Identification in Biomedical Research
This article provides a comprehensive overview of the integration of High-Resolution Mass Spectrometry (HR-MS) and Nuclear Magnetic Resonance (NMR) spectroscopy for enhanced metabolite identification in metabolomics.
Unlocking the Microbial Metabolome: A Comprehensive Guide to the DEREPLICATOR+ Algorithm for Natural Product Identification
This article provides a detailed exploration of the DEREPLICATOR+ algorithm, a transformative computational tool designed to accelerate natural product discovery by solving the critical bottleneck of dereplication—the early identification of...
Mastering the GNPS Molecular Networking Dereplication Workflow: A Complete Guide for Natural Product Researchers
This article provides a comprehensive guide to the GNPS molecular networking dereplication workflow, an essential platform for accelerating natural product and drug discovery.
Decoding Nature: A Comprehensive Guide to LC-MS/MS Profiling for Natural Product Identification and Drug Discovery
This article provides a comprehensive roadmap for researchers and drug development professionals on leveraging Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for natural product (NP) identification.
UHPLC-MS Profiling for Natural Product Library Construction: From Method Development to AI-Enhanced Discovery
This article provides a comprehensive guide for researchers and drug development professionals on constructing high-quality natural product libraries using Ultra-High-Performance Liquid Chromatography-Mass Spectrometry (UHPLC-MS).
加速天然产物发现：GC-MS代谢组学去重复化综合指南
本文为研究者和药物开发专业人员提供了关于GC-MS代谢组学在天然产物去重复化中应用的全面指南。文章系统阐述了该技术的核心原理与战略价值，详细介绍了从样品制备到数据解析的标准化工作流程。针对复杂混合物分析中常见的数据质量变异、峰重叠和假阳性识别等挑战，提供了基于最新研究的故障排除与优化策略。通过比较不同验证方法、数据标准化技术（如基于QC和模型的校正）[citation:2]以及与其他分析平台（如LC-MS、NMR）的整合，旨在建立可靠、高效的去重复化方案。本文旨在帮助读者避免已知化合物的重复分离，显著提升天然产物筛选和新药发现的效率[citation:1][citation:7]。.
Molecular Networking for Drug Discovery: A Modern Guide to Natural Product Dereplication and Identification
This article provides a comprehensive guide for researchers and drug development professionals on leveraging molecular networking (MN) to revolutionize natural product (NP) discovery.
Strategic Dereplication of Plant Extracts: Accelerating Novel Bioactive Compound Discovery
This article provides a comprehensive guide to dereplication strategies for plant extracts, tailored for researchers, scientists, and drug development professionals.
Dereplication in Natural Product Discovery: Preventing Rediscovery to Accelerate Drug Development
This article provides a comprehensive overview of dereplication strategies essential for natural product drug discovery, aimed at researchers, scientists, and drug development professionals.