Research Articles
Molecular Demolition: How Shattering a Common Molecule Unlocks Rare Medicines
Discover how chemists use furan fragmentation to create valuable alkynes for pharmaceutical synthesis, including the proposed structure of Aglatomin B.
The Tiny Ring with Mighty Power: A New Key to the Aziridine Puzzle
Discover the groundbreaking direct stereospecific synthesis of unprotected NH/NMe aziridines from olefins - a revolutionary approach in synthetic chemistry.
The Fluorine Switch: How Chemists Tamed a Capricious Molecule
Discover how chemists transformed difluoromethyl sulfoximines from electrophilic to nucleophilic compounds, enabling stereoselective synthesis of valuable fluorinated molecules.
Chiral Oxazines: The Molecular Master Key Unlocking Nature's Medicine Cabinet
Explore how chiral oxazines are revolutionizing the synthesis of polyhydroxylated alkaloids, unlocking new therapeutic potential for antiviral, anti-cancer, and anti-diabetic treatments.
The Molecular Jekyll and Hyde: How a Simple Chemical Tool Unlocks Nature's Complex Medicines
Explore how dithiane chemistry revolutionized natural product synthesis through polarity reversal and multicomponent couplings.
The Molecular Taxi: How Ortho-TMS Benzaldehyde Revolutionizes Chemical Carpentry
Discover how Ortho-TMS Benzaldehyde serves as a molecular taxi in Type II Anion Relay Chemistry, enabling efficient synthesis of complex molecules.
The Lactone Puzzle: How Synthesis and Computation Reveal Nature's Hidden Structures
Discover how chemical synthesis and computational chemistry are solving the structural mysteries of medium-sized lactones, natural products with significant pharmaceutical potential.
Unlocking Nature's Secrets: How 3-Sulfolenes Tame the Feisty Diene
Discover how 3-sulfolenes revolutionize organic synthesis by serving as stable masked dienes, enabling safer and more efficient chemical reactions.
Nature's Hidden Blueprints: The Quest to Synthesize Complex Natural Products
Exploring the synthetic challenges and breakthroughs in recreating complex natural products like platensimycin, lipstatin, and enediynes from soil bacteria.
Forging Molecular Frameworks: The Direct Approach to Alkynylated Heterocycles
Explore the revolutionary direct C-H alkynylation methods for synthesizing alkynylated heterocycles, key structures in pharmaceuticals and materials science.